A series of novel arylpiperazines were synthesized and the target compounds Travel Essential evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5-HTP induced head twitches (5-HT2A antagonism) and catalepsy studies in albino mice.The physicochemical similarity of the target compounds with respect
BackgroundIn October 2009, the French government organized a national-wide, free of charge vaccination campaign against pandemic H1N1 influenza virus, especially targeting pregnant women, a high risk group for severe illness.The study objective was to evaluate pandemic flu vaccine uptake and factors associated with non-vaccination in a population o
Cancer mortality has improved due to earlier detection via screening, as well as due to novel cancer therapies such as tyrosine kinase inhibitors and immune checkpoint inhibitions.However, similarly to older cancer therapies such as anthracyclines, these Die Grinder therapies have also been documented to cause cardiotoxic events including cardiomyo
Background Inhibitors of sodium-glucose co-transporter-2 (SGLT2i) were found to improve renal outcome in diabetic patients in large prospective randomized trials.Yet, SGLT2i may acutely reduce kidney function through volume depletion, altered glomerular hemodynamics or intensified medullary hypoxia leading to acute tubular injury (ATI).The aim or t